TYK2 and stroke disorder: Other variants in various genes were previously reported among the German population [52] (SLCO1B1 (rs4149056), PRIM1 (rs2277339), APOB (rs676210), TYK2 (rs12720356), TSEN15 (rs1046934), CYP4F2 (rs2108622), and MST1 (rs3197999)), and the Brazilians (ADAMTS (rs1364044)) [53] as risk factors for stroke in SCD patients with p-values < 1.0 × 10−5 in GWASs.