Pediatric leukemia is a heterogeneous disease, and some of the commonly observed genetic abnormalities that contribute to the development of leukemia in children include KMT2A rearrangements, fusions like ETV6-RUNX1 and BCR-ABL1, hyperdiploidy and mutations in critical genes like TP53, FLT3 and RAS [1]. The gene discussed is FLT3; the disease is leukemia.