Despite having been predicted in this present work about the benign nature and the reduction in the protein stability of TLR2 related to the presence of the SNP rs3804100 and the literary scenario more related to the patient’s worse prognosis when this gene is more expressed, in the case of the Amazonian population, significant associations for any investigated COVID-19 phenotype were not observed. This evidence concerns the gene TLR2 and COVID-19.