The aberrant alternative splicing of Fas primary transcripts can impair Fas-mediated apoptotic signaling in T cells, which can contribute to the uncontrolled proliferation of activated T cells, as seen in cutaneous T-cell lymphomas (CTCLs), a group of malignancies derived from skin-homing T cells [16]. This evidence concerns the gene FAS and primary cutaneous T-cell non-Hodgkin lymphoma.