It is worth noting that some alternatively spliced variants of T cell factors, such as IL2RA, IL7R, CD45, CD44, and CTLA-4, are associated with an increased risk of developing autoimmune diseases, such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis [10,11,12,13]. The gene discussed is CTLA4; the disease is rheumatoid arthritis.