The importance of FOXP3 in immunoregulation is highlighted by the significant associations between inactivating FOXP3 mutations and increased susceptibility to autoimmune diseases such as the IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome [51]. The gene discussed is FOXP3; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.