A plausible role for NEGR1 in the neurodegenerative disorder Huntington’s disease has been reported by Kaltenbach et al. [97], who showed that the mutated form of huntingtin interacts with NEGR1 and that the latter is able to modify a neurodegeneration phenotype induced by treatment with a huntingtin fragment in Drosophila. The gene discussed is HTT; the disease is Huntington disease.