TNF and acute lymphoblastic leukemia: Our analysis showed that while most of the Hallmarks were either over- or under-expressed uniformly among the cell lines, a small subset of Hallmarks presented differential enrichment scores across the lineages, including TNF-α signaling via NF-κB (Figure 2a), with the BCP-ALL cell lines exhibiting a higher ssGSEA NES compared to the T-ALL cell lines (Figure 2b).