TNF and acute lymphoblastic leukemia: Interestingly, TNF-α induced MTX resistance only in the BCP-ALL cell line, REH; the cytokine was lethal to CCRF-CEM and 697 at the highest dose tested (100 ng/mL daily) and stimulated cell proliferation—which was not accompanied by an increase in MTX resistance—in the T-ALL cell lines Molt4, T-ALL-1, and ALL-SIL (Figure S4).