In fact, tumor necrosis factor α (TNF-α), the cytokine that triggers NF-κB signaling, is involved in all stages of leukemogenesis, from cell transformation, proliferation, angiogenesis, and extramedullary infiltration to its participation in the tumor microenvironment and in leukemic cells’ immune evasion, survival, and resistance to chemotherapy [12]. This evidence concerns the gene TNF and neoplasm.