As we observed, in this family, treatment with low doses of thiazide and/or indapamide seems to correct all manifestations of GS because thiazide and indapamide may inhibit Na+, Cl− cotransporter (NCC) [27], and reduce salt reabsorption, leaving more Na+ to be exchanged for K+, which is probably excreted through the flow-stimulated maxi-larger K+ channel (BK). This evidence concerns the gene SLC12A3 and Gerstmann syndrome.