We applied the EDSP strategy to the untreated offspring of hypertensive parents to validate two previous loci associated with hypertension: (i) the Gordon’s syndrome (psuedohypoaldosteronism type II, PHA type 2) locus on chromosome 17, including the WNK4 gene [22,23], and (ii) the ROMK locus on chromosome 11 which was identified in our first GWS for hypertension [21]. The gene discussed is KCNJ1; the disease is Hypertension.