Cleft lip/palate-ectodermal dysplasia syndrome (CLPED1, OMIM#225060) is caused by the homozygous pathogenic mutation in the NECTIN1 gene, with clinical features including cleft lip and palate, ectodermal dysplasia, and mental retardation [17,18]. The gene discussed is NECTIN1; the disease is Zlotogora-Ogur syndrome.