NFκB1 mutations known to cause p50 haploinsufficiency have been associated with Common Variable Immunodeficiency (CVID), autoinflammatory and rheumatologic diseases, gastrointestinal manifestations, lymphoproliferation, and an increased risk of many types of opportunistic infections ranging from viral to fungal in nature [17]. The gene discussed is NFKB1; the disease is Opportunistic infection.