More recent works by Pedicone and colleagues [76] showed that K306, a SHIP1-selective agonist, suppresses induction of inflammatory cytokines and iNOS expression in microglia, reduces TNF-α production, and enhances the degradation of synaptosomes and apoptotic neurons by microglia, revealing novel SHIP1-regulated functions that may be of potential therapeutic benefits in various dementias. The gene discussed is INPP5D; the disease is dementia.