Whilst to our knowledge, levels of SHIP1 have not been measured in human AD brain, NF-κB levels, as measured by levels of its p65 subunit, are known to be significantly increased, particularly in the cortex, hippocampus and entorhinal cortex [65,66,67], frontal cortex [68] and basal forebrain [69]. This evidence concerns the gene INPP5D and Alzheimer disease.