PPIP5K2 and hearing loss, autosomal recessive: PPIP5K2 is associated with autosomal recessive deafness, but there is a paper that proposes it as the cause of keratoconus in an unrelated American family and in an unrelated European family, where two autosomal dominant missense variants were detected in the phosphatase domain of the p.(Ser419Ala) and p.(Asn843Ser) genes, respectively.