Of the genes suggested in this article as likely causative of keratoconus, 63% had already been linked in at least one article to the disease, and 37% are proposed as possible genes involved in its development (GUCY2D, SLC8A3, DUXA, CPMD8, KRT7, KRT9, GRHL1, CDH23, CDHR1, SLC4A4, ALDH1A2, CPSF3, ADAMST7, IMPG2, COL23A1, ITGB4, INPPL1, IDUA). This evidence concerns the gene GUCY2D and keratoconus.