Given the importance of the function of metalloproteinases and, in particular, the participation of MMP-1 in the proper deposition of ECM in the stroma, it can be speculated that the incorrect function of MMP-1 and MMP-2 proteins could lead to ECM disruption and the incorrect cross-linking of collagen bundles, which can generate the Vogt’s striae that appear from grade 2 keratoconus onwards. This evidence concerns the gene MMP2 and keratoconus.