ITM2C expression exhibited a strong correlation with the Act_B (rho = 0.146, p = 0.00172) and Neutrophils (rho = 0.126, p = 0.00692) levels in colon cancer and with the Act_B (rho = 0.329, p = 1.58 × 10−5) and Neutrophils (rho = 0.27, p = 0.000433) levels in rectal cancer. This evidence concerns the gene ITM2C and malignant colon neoplasm.