CA2 expression exhibited a strong correlation with the Act_B (rho = 0.3, p = 6.68 × 10−11), Act_DC (rho = 0.356, p = 4.43 × 10−15), and Neutrophils (0.329, p = 6.04 × 10−13) levels in colon cancer and with the Act_B (rho = 0.362, p = 1.86 × 10−6), Act_DC (rho = 0.38, p = 3.92 × 10−7), and Neutrophils (rho = 0.359, p = 2.21 × 10−6) levels in rectal cancer. Here, CA2 is linked to malignant colon neoplasm.