NECTIN2 and Alzheimer disease: Interestingly, while most alleles with elevated risks for CHD and MI (rs7412_C: βCHD = 0.12, p = 8.25 × 10−8; and rs423958_c: βCHD = 0.06, p = 2.90 × 10−4) were associated with higher risk of AD (rs7412_C: βAD = 0.86, p = 1.87 × 10−5; and rs423958_c: βAD = 1.37, p = 4.63 × 10−71), rs283813 (PVRL2 gene) demonstrated the opposite relationship, i.e., rs283813_a was favorably associated with CHD (βCHD = −0.05, p = 3.01 × 10−2) but adversely with AD (βAD = 0.49, p = 7.16 × 10−5).