To determine the dynamic changes in IL8 expression during NASH progression, we analyzed publicly available RNA sequencing (RNA-seq) data from patients with NAFLD (GSE135251 and GSE167523), which have been recently published with the information for hepatic gene expression compared between individuals with different stages of NASH as well as fatty liver [27,28]. The gene discussed is CXCL8; the disease is metabolic dysfunction-associated steatotic liver disease.