We further revealed that IL-22 could mitigate Cxcl1 overexpression-induced liver injury in HFD-fed mice through a mechanism that required the induction of the antioxidant enzymes metallothionein-1 and metallothionein-2, thereby suggesting that attenuation of oxidative stress could ameliorate neutrophil-driven experimental NASH. The gene discussed is MT2A; the disease is metabolic dysfunction-associated steatohepatitis.