These nanoparticles effectively promoted tumor cell death in vitro and potent CXCR4-dependent anti-tumor effects without systemic toxicity in CXCR4+ tumor mouse models of lymphoma [108,110], colorectal [111], endometrial cancer [109], and acute myeloid leukemia [112]. The gene discussed is CXCR4; the disease is acute myeloid leukemia.