The benefits of Vitamin D supplements in the treatments of MetS and its disorders connected include improved arterial stiffness, mitochondrial oxidation, and phospholipid metabolism; increased lipoprotein lipase activity, peripheral insulin sensitivity, and β-cell function; and decreased inflammatory cytokines and parathyroid hormone levels and renin–angiotensin–aldosterone system activity [205,206,207]. The gene discussed is LPL; the disease is metabolic syndrome.