REN and secondary hyperparathyroidism: Also, vitamin D is known as an antihypertensive agent because of its direct effect on vascular cells, suppression of the renin–angiotensin–aldosterone system, calcium metabolism, and prevention of secondary hyperparathyroidism [209], in particular, parathyroid hormone (PTH), which is also involved in the process of lipogenesis; Vitamin D deficiency can favor greater adiposity by promoting an increase in parathyroid hormone levels and the inflow of calcium in adipocytes, thus increasing lipogenesis and inhibiting the lipolysis in adipocytes [210].