Take CD8+ T cells, for example, which can kill tumor cells and inhibit keloid fibroblast proliferation; studies have shown that clonal expansion of the effector and exhausted tumor-infiltrating CD8+ T cells is observed for various human cancers [74], while the number of CD8+ T cells in the keloid microenvironment and peripheral blood is reduced compared to in healthy people [18]. The gene discussed is CD8A; the disease is cancer.