NPPB and hydrops fetalis: The impact of HF medications on worsening renal function (WRF) and the link to outcome was examined in a post hoc analysis of TIME-CHF (NT-proBNP-guided vs. symptom-guided treatment in chronic HF) trial which comprised patients with LVEF ≤45% and ≥1 follow-up visits (n = 462) [117].