In BC plasma, the expressions of the sEV ALB, COL1A1, CSN1S1, EEF1A2, and RPL3 were significantly upregulated, while the expressions of C1S, C5, C7, and CFHR2 were downregulated, and these dysregulated proteins are considered as biomarker candidates for BC diagnosis. This evidence concerns the gene RPL3 and breast cancer.