Despite the previous discovery of COL1A1 [55], EEF1A2 [56,57], and RPL3 [58] as metastasis-related proteins in BC and CSN1S1 [59], C5 [60], and C7 [61] as BC prognosis-related proteins, the function or biomarker potential of these proteins within sEVs remains unknown. This evidence concerns the gene RPL3 and breast cancer.