The significantly overexpressed sEV proteins in the BC plasma-derived UCT isolates were ALB, COL1A1, CSN1S1, EEF1A2, and RPL3; and the C1S, C5, C7, and CFHR2 sEV proteins in the UCT isolates were the most downregulated proteins in the BC plasma compared to the non-cancer control. The gene discussed is C1S; the disease is cancer.