We found that AR, CAV1, ICAM1, MMP2, TNFRSF1A, AGT, CASP8, CCR5, and CXCL12 were significantly up-regulated in AD patients compared with controls, while CDK5, GRIN, MAPT, BACE1, GRIN2B, and GRIN3B were significantly down-regulated in AD patients compared with controls. The gene discussed is GRIN3B; the disease is Alzheimer disease.