The KEGG pathways mainly involved Alzheimer’s disease (hsa05010), neuroactive ligand-receptor interaction (hsa04080), calcium signaling pathway (sa04020), pathways in cancer (hsa05200), serotonergic synapse (hsa04726), and EGFR tyrosine kinase inhibitor resistance (hsa01521) (Figure 3a, Table S4). The gene discussed is EGFR; the disease is early-onset autosomal dominant Alzheimer disease.