AGER, CACNA1C, CASP8, CDK5, GRIN1, GRIN2B, GSK3B, LPL, MAPT, MME, NOS2, ADAM17, TNFRSF1A, CDK5R1, BACE1, BACE2, UCHL1, and PINK1 were found to be enriched in the AD pathway. This evidence concerns the gene CASP8 and Alzheimer disease.