Analyzing the genetic expression of proteins key to the TNF-α-necroptosis pathway in CCI and SNI neuropathic pain models, we detected the expression and cell localization of necroptosis-related proteins, including RIP1/p-RIP1, RIP3/p-RIP3, and MLKL/p-MLKL, in the ACC of SNI rats. This evidence concerns the gene MLKL and neuropathic pain.