By contrast, decreasing the activity of the ACC network by inhibiting ACC pyramidal neurons and stimulating the Gs-coupled dopamine-D1 receptor to open the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels significantly lessens input resistance and excitability, thus attenuating nociceptive responses and negative emotional behaviors in animal models of neuropathic pain [1]. This evidence concerns the gene DRD1 and neuropathic pain.