PIEZO2 and channelopathy: It is noteworthy that the suggested excessive mechanotransduction of Piezo2 containing proprioceptive sensory afferents, also found in muscle spindles and tendons, in the presence of a gain-of-function Piezo2 mutation (which is certainly an inherited form of Piezo2 channelopathy) indeed causes joint stiffness and contractures and disrupts musculoskeletal developments [26], as was theorized earlier in mussels [3,17].