PIEZO2 and channelopathy: Correspondingly, we hypothesize that the initiating bi-phasic and bi-compartmental (facet joints and entheseal compartments) Piezo2 channelopathy, in an analogous way like in DOMS [20], induced impaired Piezo2-Piezo1 crosstalk will lead to transcription activation, and if underlying mutations, like allelic variants of the HLA-B27 genotype, are present, then AS could evolve with Piezo2 channelopathy chronification, and that is the suggested activated gateway reflex, or the tertiary injury phase of Piezo2 channelopathy [10].