It is important to note that the bidirectionality of the pathophysiology that could lead to Piezo2 channelopathy in DED is emphasized, meaning that prolonged overstimulation of Piezo1 mechanotransduction could also lead to Piezo2 channelopathy, like in the case of direct non-contact neural microdamage of Piezo2 [10]. This evidence concerns the gene PIEZO1 and channelopathy.