Moreover, the Piezo2 channelopathy theory proposes that during allostatic stress, if the Piezo2 channels are microinjured, they cannot sustain their inactivated gating mechanism, hence they become leaky to unbalanced subthreshold calcium currents [10,17] and intracellular stress buffering is impaired, leading to the aforementioned upregulation of UPR. The gene discussed is PIEZO2; the disease is channelopathy.