The downstream impact of this critical neuroimmune link has been demonstrated earlier, since the proposed impaired crosstalk between Piezo2 and Piezo1 is theorized to downregulate Piezo1 on corneal Langerhans cells (LC), leading to their activation in DED secondary to autoimmune diseases [36], like is observed in rheumatoid arthritis (RA) [51], systemic lupus erythematosus (SLE) [52] and AS [53], in addition to the aforementioned corneal nerve regeneration disruption in RA [36] and SLE [35]. Here, PIEZO1 is linked to systemic lupus erythematosus.