It may also arise from de novo AML, in which CBFB::MYH11, GATA2::MECOM, KMT2A::AFDN, PML::RARA, or RUNX1::RUNX1T1 are rearranged at diagnosis [20,21,22,23,24,25,26,27]. The gene discussed is AFDN; the disease is acute myeloid leukemia.