Overall, the AML driver genes include (according to frequency) FLT3, NPM1, DNMT3A, NRAS, IDH1/2, RUNX1, TET2, WT1, ASXL1, PTPN11, SRSF2, TP53, CEBPA, BCOR, KMT2A, and KRAS [30]. The gene discussed is PTPN11; the disease is acute myeloid leukemia.