SFRP1 and heart disorder: MiRNA-1 plays an important role in chordoma tissues [40] and various types of cardiac diseases [41]; miR-1, regulated by mammalian targeting of rapamycin (mTOR), has emerged as a key regulator of skeletal muscle development through governing the distinct stages of myogenesis [42], and the SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development [43].