Astrocytic GJ Cx43 was strongly dysregulated in the anterior horns of the spinal cords of mutant SOD1G93A transgenic mice during disease progression and at the end stage, suggesting that the GJ disruption can aggravate MN death, contributing to glutamate excitotoxicity and ALS progression [277]. Here, GJA1 is linked to amyotrophic lateral sclerosis.