As confirmation of this scenario, Cx43 overexpression was described in the SOD1G93A mouse model as well as in post-mortem motor cortex, spinal cord, and cerebrospinal fluid derived from ALS patients; accordingly, neuroprotection through Cx43 blockers and Cx43 hemichannel blockers was shown to be beneficial [279]. This evidence concerns the gene GJA1 and amyotrophic lateral sclerosis.