The author showed that five genes (SOD1, CAT, GSTP1, PTGS2, TNF), two miRNAs (hsa-miR-26b-5p and hsa-miR-143-3p), and transcription factors (DR1 and HNF4) are possible key components related to combined heavy metals and glioma development [40]. Here, PTGS2 is linked to central nervous system cancer.