PBM may promote nerve recovery following ischemic stroke by converting the M1 microglial phenotype into the anti-inflammatory M2 phenotype [48] or reducing the expression of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, which are involved in pro-inflammatory responses in the M1 or M2 microglial phenotype [50]. This evidence concerns the gene TNF and ischemic stroke.