As previous studies have demonstrated, impairment of the functionality and expression of ion channels like transient receptor potential vanilloid 1 (TRPV1), transient receptor potential ankyrin 1 (TRPA1), calcium-activated potassium channel 3.1 (KCa3.1), and voltage-gated sodium channel (NaV) 1.7 and 1.8 is associated with FD pain-like development in especially the GLA KO mouse model [60,66,67,68]. The gene discussed is GLA; the disease is Fabry disease.