Since MMP-3 is involved in different physiological and pathological processes, including accumulation of inflammatory cells, stimulation of neo-angiogenesis, and supporting osteoclast differentiation simultaneously with inhibition of osteoblastogenesis and MSC proliferation, PoPEx could support all these mechanisms in P-GMSCs which are relevant for the inflammation control in chronic periodontitis. Here, MMP3 is linked to chronic periodontitis.