MTHFR and endometriosis: Indeed, in 2022, Clément et al. reported a higher prevalence of the C677T homozygous polymorphism (OR 1.74) and a lower prevalence of the MTHFR wild-type (OR 0.42) in 158 infertile women with endometriosis compared to 1430 infertile controls without endometriosis [17].