TGFB1 and open-angle glaucoma: For example, the miR-29 family, which includes miR-29a, miR-29b-1, miR-29b-2, and miR-29c, plays an essential role in the development of fibrosis in POAG, owing to their antifibrotic effects on the TGF-β signaling pathway and the production and deposition of ECM [88].