Considerable evidence indicates that inflammation-derived molecules that include tumor necrosis factor-α (TNF-α) and the Fas ligand play an important role in the etiology of glaucoma [124,125,126,127,128,129,130,131,132,133,134,135,136], while other studies point to the role of TNF-α, interleukin 1-α (IL1α), and C1q in causing astrocytes to acquire neurotoxic properties and secrete long-chain saturated lipids that lead to RGC death [137,138]. The gene discussed is TNF; the disease is glaucoma.