CRP and Other metabolic disease: Figure 4 shows that miRNA-146 in the overall cohort and miRNA-24 and -146 in men play a pivotal role in properly classifying patients into the DAS28 > 3.2 group. Finally, miRNA-24, -146 and -Let7a play pivotal roles in classifying patients into the PAT-ESR group in the overall cohort, as do miRNA-24 and -146 in women. When we studied whether these miRNAs were associated with inflammation in healthy subjects and in patients with metabolic disorders, we observed that neither miRNA-24, -146 nor -Let7a were associated with ESR or C-reactive protein in either group (Supplementary Table S2).