FOXO1 and Insulin resistance: Moreover, it was found that salsalate and adiponectin ameliorated palmitate-induced insulin resistance in hepatocytes by inhibiting the selenoprotein P via the AMPK-Forkhead box protein O1α (FOXO1α) pathway, suggesting that this action might be a novel mechanism in mediating the antidiabetic effects of salsalate and adiponectin [143,144].