MSRB1 and obesity due to melanocortin 4 receptor deficiency: Experiments studying diet-induced obesity in HFD-fed subjects, with 45% calories from fat, reduced both MsrA and MsrB (predominantly MsrB1, also known as SELENOR) activities and also their protein abundance in VAT (visceral adipose tissue) but not in SAT (subcutaneous adipose tissue) [130].