GPX4 and metabolic dysfunction-associated steatotic liver disease: Moreover, Zhu et al. identified several upregulated selenoproteins in mild NAFLD liver samples compared to healthy controls, such as SELENON, SELENOP, SELENOT, SELENOW, DIO2, DIO3, GPx4, and GPx5, suggesting that in NAFLD, selenium-related processes are progressively perturbed [90].