ISG15 and idiopathic pulmonary fibrosis: Furthermore, the transcriptome sequencing results of the lungs of IPF mice showed that ZBP1, IFN-related genes such as ISG15, interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), and IRF7 were significantly upregulated, indicating that IFN- and ZBP1-mediated PANoptosis may happen in IPF [112].