The ZBP1-PANoptosome also participates in tumor regression, and this process is regulated by an RNA modification enzyme, adenosine deaminase acting on RNA 1 (ADAR1), which contains the homologous Zα domain, through which it can bind with ZBP1 directly and block the sensor of intracellular Z-NA [137,138,139]. Here, ZBP1 is linked to neoplasm.