The inhibition of caspase-8 or knockout of caspase-8 and RIPK3 simultaneously can alternatively affect the activation of caspase-1 and GSDMD in PAH mice, indicating the possibility of the assembly of the PANoptosome as caspase-8 is a key component of the multi-protein scaffold and an important regulator of PANoptosis, but more experiments including Co-IP are necessary to verify the existence of the PANoptosome in this process [148]. Here, RIPK3 is linked to pulmonary arterial hypertension.