Furthermore, the transcriptome sequencing results of the lungs of IPF mice showed that ZBP1, IFN-related genes such as ISG15, interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), and IRF7 were significantly upregulated, indicating that IFN- and ZBP1-mediated PANoptosis may happen in IPF [112]. The gene discussed is ZBP1; the disease is idiopathic pulmonary fibrosis.