TP53 and Epstein-Barr virus infection: ACRG classified GC into four subtypes: the MSI subtype, predominantly Lauren intestinal type with early clinical staging (stage I or II) and the best prognosis; MSS/EMT subtype, displaying a significantly lower age of onset than other subtypes, with the absent expression of cell adhesion gene CDH1, mostly corresponding to Lauren diffuse type, late staging (stage III or IV), and the worst prognosis among the four subtypes; MSS/TP53+ subtype, with a higher frequency of EBV infection; and the MSS/TP53- subtype, enriched with HER-2 gene amplifications [4].