Therefore, we aimed to assess the levels of specific cytokines, namely IL-1β IL-6, IL-8, IL-10, IL12p70, and TNF, and chemokines, IFN-α (interferon α), IP-10 (interferon γ-induced protein 10 or CXCL10), and MIG (monokine induced by γ or CXCL9) in the serum of AAV patients, taking into account various factors that could influence the levels of the cytokines tested, including the activity of the disease, the type and titre of the ANCA antibodies, the inflammatory status, and the kidneys’ condition. This evidence concerns the gene CXCL8 and anti-neutrophil cytoplasmic antibody-associated vasculitis.