Stromal cell-derived factor-1 (SDF-1), also known as chemokine C-X-C ligand 12 (CXCL12), is an important chemokine that is detectable in primary atherosclerotic plaques and exerts multiple roles in atherosclerosis through its classical C-X-C motif chemokine receptor 4 (CXCR4) receptor and alternative C-X-C motif chemokine receptor 7 (CXCR7) [1]. The gene discussed is ACKR3; the disease is atherosclerosis.