KL and depressive disorder: Additionally, studies on the safety and effectiveness of biofield therapy or TRI 360TM capsules (proprietary nutraceutical combination) in patients with one or more psychiatric symptoms (depression, anxiety, asthenia, sleep disorders, etc.)have shown an increase in the level of Klotho in blood serum, accompanied by a decrease in the level of pro-inflammatory cytokines and markers of oxidative stress [97,98].