Although Sartorius et al. (2019) showed no effect of 4-week administrations of escitalopram, venlafaxine, and buprorion on Klotho levels, another research team found a strong association between two single-nucleotide polymorphisms (SNPs) of the KL gene in response to selective serotonin reuptake inhibitor (SSRI) treatment in patients (>65 years) diagnosed with late-life MDD [109,110]. The gene discussed is KL; the disease is major depressive disorder.