GNB3 and Left ventricular dilatation: Univariate analysis, performed to assess which other non-genetic factors might influence the risk of the development of an abnormal increase in LVEDD among male patients, found that the TT genotype of the GNB3 polymorphism was the only variable with a significant effect on the occurrence of an abnormal increase in LVEDD value corresponding to the left ventricular dilatation during RRT (Table 7).