Using Lats2 conditional knockout mice, we demonstrated that proximal tubule-specific Lats2 ablation exacerbated ischemic AKI-induced tubular maladaptive repair, leading to more severe tubulointerstitial fibrosis, inflammatory cell infiltration, tubular apoptosis, and upregulation of p53 than control mice. The gene discussed is LATS2; the disease is acute kidney injury.