Moreover, ES likely originates from neural crest or mesenchymal stem cells and is the prototypical cancer type defined by a single specific genetic alteration, namely a chromosomal translocation wherein fusions occur between the EWS RNA Binding Protein 1 (EWSR1) gene and one of the ETS family genes (FLI-1), resulting in an aberrant transcription factor that reprograms gene expression. Here, EWSR1 is linked to cancer.