AR and neoplasm: Observations of chemosensitization of PCa cells in vitro following intracellular iron depletion, which has been reported in past research, may be attributed to a complex interaction between iron metabolism pathways and pathways involved in inflammation signaling, immunity, AR signaling, and tumor suppression, perhaps specifically those mediated through N-myc downstream regulated gene 1 (NDRG1) [65,66].