In order to explore the role of geniposide regulating oxidative stress against colorectal cancer, we intersected the targets of geniposide with the most critical module genes and oxidative stress-related genes in CRC, and obtained a total of 34 core genes as shown in Figure 4, including DNMT1, HSP90AA1, PTPN1, ESR1, PTK2, RELA, CDK4, CDK5, ADRB1, MAPKAPK2, TRPV1, CDK2, NOS3, JAK2, MIF, GSK3B, ACHE, MMP3, NR3C1, HSP90AB1, ADRB3, MMP1, BCL2, ELANE, HDAC2, RAC1, PRKCB, BCL2L1, GAPDH, HSPA8, HSPA5, CHEK1, FOXO1, IL1B. This evidence concerns the gene HSPA8 and colorectal cancer.