KEGG pathway enrichment analysis showed that there were 87 signaling pathways (p-value < 0.05) in which geniposide-regulated oxidative stress intervened in CRC, mainly involving pathways in the cancer signaling pathway, PI3K–Akt signaling pathway, IL-17 signaling pathway, p53 signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway. This evidence concerns the gene TP53 and cancer.