In order to explore the role of geniposide regulating oxidative stress against colorectal cancer, we intersected the targets of geniposide with the most critical module genes and oxidative stress-related genes in CRC, and obtained a total of 34 core genes as shown in Figure 4, including DNMT1, HSP90AA1, PTPN1, ESR1, PTK2, RELA, CDK4, CDK5, ADRB1, MAPKAPK2, TRPV1, CDK2, NOS3, JAK2, MIF, GSK3B, ACHE, MMP3, NR3C1, HSP90AB1, ADRB3, MMP1, BCL2, ELANE, HDAC2, RAC1, PRKCB, BCL2L1, GAPDH, HSPA8, HSPA5, CHEK1, FOXO1, IL1B. The gene discussed is ESR1; the disease is colorectal carcinoma.