DSG2 and arrhythmogenic right ventricular cardiomyopathy: In the context of ARVC, it has been observed that patients with mutations in the DSP, desmocollin-2 (DSC2), and DSG2 genes more commonly exhibit a diminished left ventricular ejection fraction (LVEF) of ≤45% on cardiac magnetic resonance (CMR) imaging in comparison to those with PKP2-related ARVC (27% vs. 4%, p < 0.01) [116].