Individuals harboring mutations in genes such as DSP, LMNA, PLN, FLCN, RBM20, and TMEM43 are more susceptible to significant arrhythmic events, irrespective of their LVEF, and tend to follow a more challenging clinical trajectory than those with DCM who are genotype-negative. The gene discussed is TMEM43; the disease is familial dilated cardiomyopathy.