MALAT-1 is downregulated in preeclampsia and regulates JEG-3 trophoblast cell proliferation, apoptosis, migration, and invasion. It works through the VEGF/VEGFR1 signaling pathway and in mesenchymal cells it promotes immunosuppressive properties as well as proliferation and angiogenesis through the induction of VEGF and IDO. In Dendritic Cells, influences the immune response and apoptosis mediated by TLR9/STAT3 signaling. In addition, induced the invasion and migration of cytotrophoblasts via PI3K/Akt. This evidence concerns the gene AKT1 and preeclampsia.