Inhibition of endogenous MEG-3 increases apoptosis and decreases migration of HTR-8/SVneo and JEG3 cells. In addition, MEG-3 influences the expression of NF-κB, Caspase-3, and Bax proteins in trophoblast cells. This could lead to aberrant conditions in HTR-8/SVneo and JEG3 trophoblastic cells, associated with uterine spiral artery remodeling and progression to preeclampsia. This evidence concerns the gene BAX and preeclampsia.