We then developed a murine model of FTAAD that possesses K1256del of Myh11 (where heterogeneous and homogeneous mutations are denoted as Myh11ΔK/+ and Myh11ΔK/ΔK, respectively) [7]. The gene discussed is MYH11; the disease is familial thoracic aortic aneurysm and aortic dissection.