In a mouse model of acute liver failure induced by D-galactosamine (D-GalN) and lipopolysaccharide (LPS), transplantation of human UC-MSCs was shown to inhibit not only apoptosis and inflammation but also pyroptosis by suppressing NLRP3 inflammasome activation, IL-1β maturation, and caspase 1 cleavage [88]. The gene discussed is NLRP3; the disease is acute liver failure.