PDZD8 and cancer: In addition, it was shown that hUCMSC-exos significantly reduced the phosphorylation of proteins involved in nuclear transport and cancer signaling in hepatocytes, including heat shock protein HSP90-beta (Hsp90ab1) and nucleoprotein TPR, and increased the phosphorylation of proteins involved in the intercellular communication, such as calnexin and PDZ domain-containing protein 8 (Pdzd8) [262].