Caveolin-1 (Cav1) constitutes caveolae majorly in terms of structure and function; once its expression is dysregulated, patients may be prone to not only melanoma but also non-melanoma skin cancer (NMSC) [40] and other hyperproliferative disorders, such as psoriasis (Figure 4) [41]. Here, CAV1 is linked to non-melanoma skin carcinoma.